Relationship of vitamin B12, folic acid and homocysteine level with time domain measures of heart rate variability in female Metabolic Syndrome

Background: Metabolic syndrome (MetS) is a major risk factor for cardiac mortality and morbidity. Hyperhomocysteinemia folic acid are related with MetS. Both MetS hyperhomocysteinemia adversely affect heart rate variability (HRV). Objectives: To assess the relationship of vitamin B12, homocysteine levels HRV in female patients. Methods: This cross sectional study was carried out on 40 patients 25-45 years age. Forty apparently healthy similar age were control. Chemiluminescent immunoassay measured serum acid, level time domain parameters recorded by Powerlab 8/35, AD instruments, Australia. Independent sample ‘t’ test pearson correlation coefficient used statistical analysis Results: In this study, all variables ( Standard deviation RR intervals-SDRR, Coefficient variation interval-CVRR, The square root mean squared difference intervals-RMSSD Number R-R interval differing >50ms from adjacent intervals divided total number intervals-pRR50%) significantly lower (p<0.05) compared to But showed only negatively correlated SDRR, CVRR, RMSSD pRR50%. Conclusion: result inverse relation low J Bangladesh Soc Physiol. 2022, June; 17(1): 41-48